EPO (erythropoietin) is a naturally occurring hormone which is works to stimulate the production of new red blood cells. Increasing the number of red blood cells helps to enhance the oxygen-carrying capacity of the blood. What this means is that during exercise more oxygen is fed to the working muscles which helps with the muscles’ ability to produce energy thereby enhancing performance output, improving intensity and helping to increase training duration.

Not only can EPO help with the elements listed above, it can also help to combat fatigue, bolster Nitric Oxide production and increase nutrient delivery, all of which can contribute to gains in lean muscle mass.

Before we go any further, please note that natural EPO is not to be confused with the performance enhancing drug rhEPO (recombinant erythropoietin) which many of you may have heard of from the Lance Armstrong doping scandal.

EPO increases oxygen in the blood

In order to produce ATP (Adenosine Triphosphate) in the muscles, oxygen is required. The greater the amount of oxygen available in the blood, the more ATP can be produced. The more ATP in the muscles, the better muscular energy and muscular contraction you will have. EPO helps to enhance blood oxygen levels so more ATP can be produced.

EPO helps build new red blood cells

Red blood cells help with the transport of oxygen and carbon dioxide in the body. Unfortunately, red blood cells do not survive long in the blood stream. It is for this reason that naturally produced EPO stimulates the production of new red blood cells. If we do not produce enough EPO, red blood cell production may be repressed. If red blood cells are not at optimal levels, the blood will not be able to transport oxygen to tissues and cells efficiently and it will limit the body’s ability to remove waste products (CO2).

Now that we know how EPO can help to increase exercise output, we need to find a way to boost EPO production naturally.

Natural EPO Boosters

To help boost natural EPO levels, there are a number of supplemental ingredients which you can use. These ingredients will help to increase EPO, red blood cell production, function and life duration, as well as to produce various other benefits which are of interest to athletes.

  • Arachidonic Acid
  • Cobalt
  • Echinacea
  • Niacin
  • Portulaca Oleracea
  • Vitamin B-6
  • Vitamin B-12

The synergistic effects of EPO and NO

NO, or nitric oxide, boosters help to increase the amount of blood flow to muscles and other tissues by causing vasodilation (dilating blood vessels). In doing so, more oxygen, nutrients and anabolic hormones are transported to muscle cells. The increased blood flow also helps to clear waste products from muscle cells.

Couple increased EPO and NO and you will be able to take advantage of their synergistically functioning effects. EPO will help to stimulate more red blood cells and increase nutrient and oxygen carrying capacity and NO will widen the blood vessels to promote a greater blood flow so that the increased red blood cells, oxygen and nutrients is driven into the muscles.

NO Boosting

In order to help enhance the effects of EPO, it is a good idea supplement with ingredients which can help to increase nitric oxide production. These include:

      • Arginine
      • Citrulline
      • Beta Vulgaris
      • NorValine
      • Methyltetrahydrofolate
      • Folate


Amplify Ampli-Pump 4.0

Ampli-Pump 4.0 is the ultimate solution to amplifying your pre-workout formula! It is a stimulant free pre-training formula that is designed to amplify your vasodilation, taken with your favourite pre-workout will take your gym sessions to the ultimate level! The newest formulation contains clinically dosed ingredients, ensuring that you are getting exactly what you need to rev up your workouts, helping you train harder for longer


By increasing both EPO and NO production through carefully formulated supplementation, you will be able to decrease fatigue, boost muscular energy, improve workout performance and increase oxygen and nutrient delivery to muscle cells. Over time, this can lead to serious lean muscle gains and improved training quality.

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